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Injury and Recovery Laboratory

Cole Vonder Haar, Ph.D.


Recent Publications

Full PubMed list

2020

  • *Modrak, C. G., *Giesler, L. P., Vonder Haar, C. Traumatic brain injury substantially reduces the conditioned reinforcing effects of environmental cues in rats. Brain Research, in press. Link
    *equal contributions
  • Frankot, M., O’Hearn, C. M. & Vonder Haar, C. Choice-based assessments outperform traditional measures for chronic depressive-like behaviors in rats after brain injury. Behavioural Brain Research, in press. Link
  • Ozga-Hess, J. E., Whirtley, C., O’Hearn, C. O., Pechacek, K. M. & Vonder Haar, C. Unilateral parietal traumatic brain injury increases risk-taking on a rat gambling task. Experimental Neurology, 327, 113217. Link
  • Vonder Haar, C. (2020). Challenges and opportunities in animal models of gambling-like behavior. Current Opinion in Behavioral Sciences, 31, 42-47. Link

    • 2019

  • Vonder Haar, C., O’Hearn, C. M. & Winstanley, C. A. (2019). Exposure to uncertainty mediates the effects of traumatic brain injury on probabilistic decision-making in rats. Brain Injury, 34(1), 140-148. Link
  • Martens, K. M., Pechacek, K. M., Modrak, C. G., Milleson, V. J., Zhu, B. & Vonder Haar, C. (2019). Cathodal transcranial direct-current stimulation selectively reduces impulsivity after TBI. Journal of Neurotrauma, 36(19), 2827-2830. Download
  • *Vonder Haar, C., *Martens, K. M., *Bashir, A., McInnes, K., Cheng, W. H., Cheung, H., Stukas, S., Barron, C., Ladner, T., Welch, K., Cripton, P., Winstanley, C. A. & Wellington, C. L. (2019). Repetitive closed-head impact model of engineered rotational acceleration (CHIMERA) injury in rats increases impulsivity, decreases dopaminergic innervation in the ventral striatum and generates white matter inflammation, tau phosphorylation and degeneration. Experimental Neurology, 317, 87-99. Download | Supplement
    *equal contributions
  • Ferland, J.-M. N., Hynes, T. J., Hounjet, C. D., Lindenbach, D., Vonder Haar, C., Adams, W. A., Philips, A. G. & Winstanley, C. A. (2019). Prior exposure to salient win-paired cues in a rat gambling task increases sensitivity to cocaine self-administration and suppresses dopamine efflux in nucleus accumbens: support for the reward deficiency hypothesis of addiction. Journal of Neuroscience, 39(10), 1842-1854. Link
  • Shaver, T. K., Ozga, J. E., Zhu, B., Anderson, K. G., Martens, K. M. & Vonder Haar, C. (2019). Long-term deficits in risky decision-making after traumatic brain injury on a rat analog of the Iowa gambling task. Brain Research, 1704, 103-113. Download | Supplement
  • Scott, T. L. & Vonder Haar, C. (2019). Frontal brain injury chronically impairs timing behavior in rats. Behavioural Brain Research, 356, 408-414. Download

    • 2018

  • *Vonder Haar, C., *Ferland, J-M. N., Kaur, S., Riparip, L-K., Rosi, S. & Winstanley, C. A. (2019). Cocaine self-administration is increased after frontal traumatic brain injury and associated with neuroinflammation. European Journal of Neuroscience, 50(3), 2134-2145. Download
    *equal contributions
  • Ozga, J.E., Povroznik, J. M., Engler-Chizurrazi, E. & Vonder Haar, C. (2018). Executive (dys)function after traumatic brain injury: Special considerations for behavioral pharmacology. (2018). Behavioural Pharmacology, 29(7), 617-637. Download
  • Povroznik, J. M., Ozga, J.E., Vonder Haar, C. & Engler-Chizurrazi, E. (2018). Executive (dys)function after stroke: Special considerations for behavioral pharmacology. (2018). Behavioural Pharmacology, 29(7), 638-653. Link

    • 2017

  • Vonder Haar, C., Martens, K. M., Riparip, L-K., Rosi, S., Wellington, C. L. & Winstanley, C. A. (2017). TBI-induced impulsivity is associated with cortical interleukin-12 levels in rats. Journal of Neurotrauma, 34(19), 2790-2800. Download
  • *Adams, W. K., *Vonder Haar, C., Tremblay, M. T., Cocker, P. J., Silveira, M. M., Kaur, S. Baunez, C., & Winstanley, C. A. Deep-brain stimulation of the subthalamic nucleus selectively decreases risky choice in risk-preferring rats. eNeuro, 0094-17.2017. Download
    *equal contributions
  • Shultz S.R., McDonald S.J., Vonder Haar, C., Meconi, A., Vink, R., van Donkelaar, P., Taneja, C., Iverson, G.L. & Christie, B.R. (2017). The potential for animal models to provide insight into mild traumatic brain injury: translational challenges and strategies. Neuroscience & Biobehavioral Reviews, 76, 396-414. Download

    • 2016

  • Vonder Haar, C., Lam, F. C. W., Adams, W. K., Riparip, L-K., Kaur, S., Muthukrishna, M., Rosi, S. & Winstanley, C. A. (2016). Frontal traumatic brain injury in rats causes long-lasting impairments in impulse control that are that are differentially sensitive to pharmacotherapeutics and associated with chronic neuroinflammation. ACS Chemical Neuroscience, 7(11), 1531-1542. Download | Supplement
  • Vonder Haar, C. & Winstanley, C. A. (2016). Minor functional deficits in basic response patterns for reinforcement following frontal traumatic brain injury in rats. Journal of Neurotrauma, 33(20), 1892-1900. Download
  • Cocker, P. J., Vonder Haar, C., Winstanley, C. A. (2016). Elucidating the role of D4 receptors in mediating attributions of salience to incentive stimuli on Pavlovian conditioned approach and conditioned reinforcement paradigms. Behavioural Brain Research, 312, 55-63. Link
  • Vonder Haar, C., Peterson, T. C., Martens, K. M., & Hoane, M. R. (2016). Vitamins and nutrients as primary treatments in experimental brain injury: Clinical implications for nutraceutical therapies. Brain Research, 1640(Pt A), 114-129. Download

    • Recent Presentations

    2020

  • Vonder Haar, C. Chronic consequences of TBI: Animal models and treatments. Current Topics in TBI Zoom Webinar. Hosted by the University of Kentucky and Trinity College Dublin. May 18th, 2020, Web.

    • 2019

    SFN/FUN, Chicago

  • Pechacek, K. M., Martens, K. M., Zhu, B & Vonder Haar, C. Inhibition of microglia using chemogenetics reduced proinflammatory cytokine levels after traumatic brain injury. Presented at the Society for Neuroscience Annual Meeting in 2019, Chicago, IL.
  • Milleson, V. J., Adkins, J. S., Martens, K. M. & Vonder Haar, C. Repeat closed-head injury selectively impairs attention in rats. Presented at the Society for Neuroscience Annual Meeting in 2019, Chicago, IL.
  • Shaver, T. K., Lafferty, C. T., Frankot M. A., Ozga-Hess, J. E., Martens, K. M. & Vonder Haar, C. Methylphenidate differentially alters risk-based decision-making in rats after TBI. Presented at the Society for Neuroscience Annual Meeting, Chicago, IL.
  • Giesler, L. P. & Vonder Haar, C. Frontal traumatic brain injury reduces the reinforcing effects of auditory cues in rats. Presented at the Faculty for Undergraduate Neuroscience poster session at the SFN Annual meeting in 2019, Chicago, IL.
  • Forte, B., Pechacek, K. M., Giesler, L. P. & Vonder Haar, C. Methylphenidate alters loss sensitivity, but fails to treat traumatic brain injury. Presented at the Faculty for Undergraduate Neuroscience poster session at the SFN Annual meeting in 2019, Chicago, IL.
  • Rodriguez, B., Frankot, M. A. & Vonder Haar, C. Decision-making deficits following brain injury are not exacerbated by high-fat diet. Presented at the Faculty for Undergraduate Neuroscience poster session at the SFN Annual meeting in 2019, Chicago, IL.

    • NNS, Pittsburgh

  • Vonder Haar, Cole. Modeling and treating chronic psychiatric-like dysfunction in rats. Presented as part of the symposium "Secondary Conditions after TBI: Headache, Neuroendocrine & Neuropsychiatric Sequelae" at the National Neurotrauma Symposium in 2019, Pittsburgh, PA.
  • Pechacek, K. M., O'Hearn, C. M., Lake, A. D. & Vonder Haar, C. Effects of chronic systemic versus central inflammatory challenge on motivation in rats. Presented at the National Neurotrauma Symposium in 2019, Pittsburgh, PA
  • O’Hearn, C. M. Frankot, M. A., Giesler L. P., Shaver, T. K., Portillo, G. R. & Vonder Haar, C. Deficits in behavioral flexibility and impulse control are rescued with cues following severe frontal brain injury in rats. Presented at the National Neurotrauma Symposium in 2019, Pittsburgh, PA.
  • Frankot, M. A., Modrak, C. G. & Vonder Haar, C. Frontal Traumatic Brain Injury Impairs Effort-Based Decision Making in Rats. Presented at the National Neurotrauma Symposium in 2019, Pittsburgh, PA.
  • Ozga-Hess, J. E. & Vonder Haar, C. Unilateral parietal TBI increases risky decisions on a rat gambling task. Presented at the National Neurotrauma Symposium in 2019, Pittsburgh, PA.
  • Modrak, C. G. & Vonder Haar, C. Frontal traumatic brain injury reduces sensitivity to cues and conditioned reinforcers. Presented at the National Neurotrauma Symposium in 2019, Pittsburgh, PA.
  • Giesler L. P., Adkins, J. S, Gondringer, A. P., Milleson, V. J., Lafferty, C. T., Martens, K. M. & Vonder Haar, C. Repeat closed-head injury impairs attention, but not impulsivity. Presented at the National Neurotrauma Symposium in 2019, Pittsburgh, PA.
  • Martens, K.M., Pechacek, K. P., Zhu, B. & Vonder Haar, C. Transcranial direct-current stimulation reduces impulsivity after experimental TBI. Presented at the National Neurotrauma Symposium in 2019, Pittsburgh, PA.

    • InSRI, Chicago

  • Vonder Haar, Cole. Long-term impairments in impulsivity and decision-making under risk following experimental brain injury. Presented at the International Society for Research on Impulsivity, 2019, Chicago, IL.

    • WCBR, Snowmass

  • Martens, K. Transcranial direct-current stimulation improves decision-making and decreases impulsivity in a rat model of traumatic brain injury. Presented as part of the symposium "Treatment for Traumatic Brain Injury: One-Size Doesn’t Fit All" at the Winter Conference on Brain Research in 2019, Snowmass, CO.

    • 2018

    SFN/FUN, San Diego

  • O’Hearn, C. M., Whirtley, C., Shaver, T. K., Carbal, C. E., Lake, A.D., Zhu, B., Richmond, A. & Vonder Haar, C. Analysis of risk-based decision making in rats following medial prefrontal stroke. Presented at the Society for Neuroscience annual meeting in 2018, San Diego, CA.
  • Ozga, J.E., Whirtley, C., O’Hearn, C.M., Bhatia, H. S., & Vonder Haar, C. Unilateral parietal traumatic brain injury increases risk-taking on a rat gambling task. Presented at the Society for Neuroscience annual meeting in 2018, San Diego, CA.
  • Modrak, C., Milleson, V., Pechacek, K., Zhu, B., O'Hearn, C., Whirtley, C., Ozga, J., Shaver, T., Portillo, G., Frankot, M., Martens, K. & Vonder Haar, C. Transcranial direct current stimulation lessens negative impulsivity effects of controlled cortical impact traumatic brain injuries in rats. Presented at the Faculty for Undergraduate Neuroscience Social at the SFN annual meeting in 2018, San Diego, CA

    • NCRG, Las Vegas

  • Vonder Haar, C., Shaver, T. K., Cabral, C. E., Zhu, B., Lake, A. D., O’Hearn, C. M., Whirtley, C., Ozga, J. E. & Martens, K. M. Impairments in probabilistic decision-making after traumatic brain injury in rats are exacerbated by methylphenidate administration. Presented at the National Center for Responsible Gaming annual conference in 2018, Las Vegas, NV.

    • INTS, Toronto

  • Lake, A. D., Whirtley, C., Bhatia, H. S., Wellington, C. L., Winstanley, C. A., Martens, K. M. & Vonder Haar, C. Addressing mild traumatic brain injury-induced heterogeneity through evaluation of individual differences. Presented at the Joint National/International Neurotrauma Symposium in 2018, Toronto, Canada.
  • Whirtley, C., Lake, A. D., O’Hearn, C. M., Ozga, J. E., Shaver, T. K., Cabral, C. E., Bhatia, H. S. & Vonder Haar, C. Effects of repeat concussions on choice, attention, and motor impulsivity in rats. Presented at the Joint National/International Neurotrauma Symposium in 2018, Toronto, Canada.
  • Scott, T. S., Cabral, C. E., Dalida, M. B., O’Hearn, C. M., & Vonder Haar, C. Frontal controlled cortical impact injury chronically decreases time-related judgments in rats. Presented at the Joint National/International Neurotrauma Symposium in 2018, Toronto, Canada.
  • Shaver, T. K., O’Hearn, C. M., Cabral, C. E., Zhu, B., Whirtley, C., Lake, A. D., Dalida, M. B., Martens, K. M. & Vonder Haar, C. Methylphenidate treatment impairs risk-based decision making without affecting impulsivity after controlled cortical impact. Presented at the Joint National/International Neurotrauma Symposium in 2018, Toronto, Canada.
  • O'Hearn, C. M., Whirtley, C., Scott, T. S., Cabral, C. E., Lake, A. D. & Vonder Haar, C. Animal models of chronic depression following severe traumatic brain injury. Presented at the Joint National/International Neurotrauma Symposium in 2018, Toronto, Canada.

    • WCBR, Whistler BC

  • Vonder Haar, C. Long-term deficits in decision-making and impulsive action following TBI in rats. Part of the symposium “Chronic Behavioral Effects of Neurological and Psychological Trauma.” Presentation given at the Winter Conference on Brain Research in 2018, Whistler, BC.
  • Vonder Haar, C. Repeat Concussions Disrupt Functions Under the Control of Frontal Circuits. Part of the symposium “Neural Circuit Disruption in Traumatic Brain Injury: Looking beyond Pathology to Network Alterations across Different Severities and Modalities.” Presentation given at the Winter Conference on Brain Research in 2018, Whistler, BC.
  • Martens, K. M. & Vonder Haar, C. Repeat concussion causes impairments in attention and motor impulsivity. Presented at the Winter Conference for Brain Research annual meeting in 2018, Whistler, BC.