Welcome to The SHI Group
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Welcome to The SHI Group |
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It has been demonstrated that non-covalent interactions are crucial in both chemical and biological processes. Properly designed systems utilizing non-covalent interactions as the driving force in frame construction and substrate activation are certainly attractive to both chemists and biologists. Our research goals are to develop systems that employ non-covalent interactions for efficient and specific structure control, and to utilize these new systems in various biological and chemical processes. The projects proposed include: 1) design and synthesis of (covalently or non-covalently) stabilized G-quartet; 2) K+ ion channel recognition and telomerase inhibition by self-assembled G-quartet; 3) design and synthesis of ion-conducting materials mediated by self-assembled G-quartets; 4) developing proline and prolinol derivatives as chiral Lewis and Brønsted base catalysts in asymmetric synthesis. Studies of these systems are expected to contribute to both fundamental understanding of molecular interactions and applications in biological target recognition.
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Last Update 09/05/2005 |
